Key Publications for ME/CFS & Long Covid

Contents

General Guidelines | Children | Patient Safety

Systems Muscle/Exercise | Neurological | Vascular | Immunological | Coagulation

Cellular Metabolic | Mitochondria | Amyloid | Biomarkers

Guidelines / Overview

A Long COVID Definition: A Chronic, Systemic Disease State with Profound Consequences

Myalgic encephalomyelitis or encephalopathy/chronic fatigue syndrome: diagnosis and management

Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness

Long COVID: major findings, mechanisms and recommendations

Long Covid in Aotearoa NZ: Risk assessment and preventive action urgently needed

NICE guideline on ME/CFS: robust advice based on a thorough review of the evidence

Children

Characterizing Long COVID in Children and Adolescents

Characteristics and predictors of Long Covid in children: a 3-year prospective cohort study

Pediatric SARS-CoV-2 long term outcomes study PECOS: cross sectional analysis at baseline

Patient Safety

Management of Nutritional Failure in People with Severe ME/CFS: Review of the Case for Supplementing NICE Guideline NG206

Life-Threatening Malnutrition in Very Severe ME/CFS

Maeve Boothby O'Neill: Prevention of Future Deaths Report

Caring for the Patient with Severe or Very Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Medical ambivalence and Long Covid: The disconnects, entanglements, and productivities shaping ethnic minority experiences in the UK

Graded exercise therapy for myalgic encephalomyelitis/chronic fatigue syndrome is not effective and unsafe. Re-analysis of a Cochrane review

Rethinking the treatment of chronic fatigue syndrome—a reanalysis and evaluation of findings from a recent major trial of graded exercise and CBT

The biological challenge of myalgic encephalomyelitis/chronic fatigue syndrome: a solvable problem

Muscle / Exercise

The metabolic and physiologic impairments underlying long COVID associated exercise intolerance

Skeletal muscle adaptations and post-exertional malaise in long COVID

Muscle abnormalities worsen after post-exertional malaise in long COVID

Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome cases and sedentary controls in response to maximal exercise

Differential Cardiopulmonary Hemodynamic Phenotypes in PASC Related Exercise Intolerance

Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles

Stress-Induced Transcriptomic Changes in Females with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Reveal Disrupted Immune Signatures

Unexplained exertional intolerance associated with impaired systemic oxygen extraction

Inability of myalgic encephalomyelitis/chronic fatigue syndrome patients to reproduce VO2peak indicates functional impairment

Neurological

Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment

The Cardiac Output–Cerebral Blood Flow Relationship Is Abnormal in Most Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients with a Normal Heart Rate and Blood Pressure Response During a Tilt Test

Worsening Symptoms Is Associated with Larger Cerebral Blood Flow Abnormalities during Tilt-Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ME/CFS

Long COVID Is Not a Functional Neurologic Disorder

Vascular / Endothelium / Red Cells

Sustained Vascular Inflammatory Effects of SARS-CoV-2 Spike Protein on Human Endothelial Cells

Red Blood Cell Morphology Is Associated with Altered Hemorheological Properties and Fatigue in Patients with Long COVID

Reduced Stroke Volume and Brain Perfusion Drive Postural Hyperventilation in Postural Orthostatic Tachycardia Syndrome

CCL2-mediated endothelial injury drives cardiac dysfunction in long COVID

Endothelial dysfunction in ME/CFS patients

Cluster Analysis to Identify Long COVID Phenotypes Using 129Xe Magnetic Resonance Imaging: A Multi-centre Evaluation

Immunological

Transcriptional reprogramming primes CD8+ T cells toward exhaustion in Myalgic encephalomyelitis/chronic fatigue syndrome

Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2

Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection

Sex differences and immune correlates of Long Covid development, symptom persistence, and resolution

Immunometabolic changes and potential biomarkers in CFS peripheral immune cells revealed by single-cell RNA sequencing

Distinguishing features of Long COVID identified through immune profiling

The immunology of long COVID

Divergent adaptive immune responses define two types of long COVID

SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 PASC

Association of vascular netosis with COVID-19 severity in asymptomatic and symptomatic patients

Epigenetic memory of coronavirus infection in innate immune cells and their progenitors

Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19

Immune system adaptation during gender-affirming testosterone treatment

Coagulation

Fibrin drives thromboinflammation and neuropathology in COVID-19

Dysregulated platelet function in patients with postacute sequelae of COVID-19

Analysis of thrombogenicity under flow reveals new insights into the prothrombotic state of patients with post-COVID syndrome

Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 PASC is accompanied by increased levels of antiplasmin

Metabolic

Discriminating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and comorbid conditions using metabolomics in UK Biobank

Urine Metabolomics Exposes Anomalous Recovery after Maximal Exertion in Female ME/CFS Patients

Plasma metabolomics reveals disrupted response and recovery following maximal exercise in myalgic encephalomyelitis/chronic fatigue syndrome

Altered Fatty Acid Oxidation in Lymphocyte Populations of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome

Integrative Plasma Metabolic and Lipidomic Modelling of SARS-CoV-2 Infection in Relation to Clinical Severity and Early Mortality Prediction

A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants

Mitochondria

1H and 31P MR Spectroscopy to Assess Muscle Mitochondrial Dysfunction in Long COVID

WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome

An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients

SARS-CoV-2 Mitochondrial Metabolic and Epigenomic Reprogramming in COVID-19

Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts

Amyloid

Cell invasive amyloid assemblies from SARS-CoV-2 peptides can form multiple polymorphs with varying neurotoxicity

Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19

Proteomic Evidence for Amyloidogenic Cross-Seeding in Fibrinaloid Microclots

Amyloidogenesis of SARS-CoV-2 Spike Protein

Biomarker Discovery

Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity

Persistent Activation of Chronic Inflammatory Pathways in Long Covid

Upregulation of olfactory receptors and neuronal-associated genes highlights complex immune and neuronal dysregulation in Long COVID patients

Discriminating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and comorbid conditions using metabolomics in UK Biobank

A blood-based mRNA signature distinguishes people with Long COVID from recovered individuals

Influence of HLA-G 3′ Untranslated Region Haplotypes and SNP +3422 Gene Variants as Host Genetic Factors on the Outcomes of SARS-CoV-2 Infection During Acute and Post-Acute Phases in a German Cohort

Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19